Do you know that Nintex can handle file collections? Picture a scenario where an insurance agent inspects a property and takes some pictures for a case file. Once the agent uploads the files to Box they can fill in their form giving details of the property such as location and estimated value.
A workflow will start once the agent submits the case file, it will query the content management system; in this case, it is Box; find the appropriate files and store them in a File Collection. A task action in the workflow such as Express Approval or Assign a Task can be used to send the files to a case manager.